Isoelectric Focusing of Thyroid-Stimulating Antibody of Graves' Disease*
نویسندگان
چکیده
منابع مشابه
Thyroid-stimulating antibody in a patient with euthyroid Graves' disease.
We report an 11-year-old girl with euthyroid Graves' disease. She was referred to our clinic because of left exophthalmos without other symptoms suggestive of hyperthyroidism. Her serum concentration of free thyroxine (FT4) and free triiodothyronine (FT3) were normal, but thyroid-stimulating hormone (TSH) was below normal and impaired TSH response to TSH releasing hormone (TRH) was found. Altho...
متن کاملThyroid-stimulating hormone receptor antibody assays: recommendation for correct interpretation of results in Graves disease.
In Graves disease, the clinical uses of thyrotropin receptor [thyroidstimulating hormone receptor (TSH-R)] antibody (TRAb) measurements have been reported in the Thyroid Guidelines of the American Thyroid Association (1 ). First, TRAb measurements are used to investigate the etiology of hyperthyroidism when the diagnosis is not clinically obvious; second, a declining TRAb concentration during l...
متن کاملSignificance of thyroid microsomal antibody in Graves' disease.
Thyroid microsomal antibody (MsAb) was estimated in 48 patients with Graves' disease (15 newly diagnosed, 15 on drugs for about 4 weeks and 18 euthyroid with drug treatment) and twenty age and sex matched controls. The diagnosis of Graves' disease (GD) was based on clinical history, physical examination and thyroid function tests, viz. 131I uptake, thyroid scintigram and serum T3, T4 and TSH le...
متن کاملThyroid-stimulating Antibody Activity
To investigate the distribution of thyroid-stimulating antibody (TSAb) activity between IgG subclasses, sera from 11 patients with Graves disease (including the National Institute of Biological Standards and Control (NIBSC) Research Standard, long acting thyroid stimulator-B) were fractionated by chromatography on affinity columns of monoclonal IgG subclass antibodies or protein A to deplete al...
متن کاملDetermination of the levels of anti-thyroid-stimulating hormone receptor antibody with thyroid peroxidase antibody in Omani patients with Graves' disease.
OBJECTIVE To determine the levels of anti-thyroid-stimulating hormone receptor antibody (TRAb) and thyroid peroxidase antibodies (TPO) in Omani patients with Graves' disease (GD). SUBJECTS AND METHODS ELISA was used to measure the levels of TRAb and TPO in sera of 111 patients with GD, 40 patients with systemic lupus erythematosus (SLE) and 50 healthy normal subjects. Seventy-eight GD patient...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 1978
ISSN: 0013-7227,1945-7170
DOI: 10.1210/endo-103-4-1469